Additional file 1 of Do iron homeostasis biomarkers mediate the associations of liability to type 2 diabetes and glycemic traits in liver steatosis and cirrhosis: a two-step Mendelian randomization study

Additional file 1:  Table S1. The associations of liability to type 2 diabetes and glycemic traits in iron homeostasis biomarkers in our previous study (Liang et al., 2023). Table S2. Description of iron homeostasis biomarkers. Table S3. Information of the data sources used in this study. Table S4. Participant overlap information in the genome-wide associations studies used in this study. Table S5. The genetic instruments information of type 2 diabetes, glycemic traits, iron homeostasis biomarkers, and liver iron after harmonization. Table S6. Genetic instruments information of liability to type 2 diabetes and glycemic traits as exposures. Table S7. Genetic instruments information of iron homeostasis biomarkers as exposures. Table S8. Genetic instruments information of liver iron as exposures. Table S9. Genetic instruments information of liver steatosis, liver cirrhosis, ALT, PDFF, and liver iron as outcomes. Table S10. Genetic information of HbA1c signal classification. Table S11. Study power of this two-step Mendelian randomization study. Table S12. The associations of liability to type 2 diabetes and glycemic traits in liver steatosis, liver cirrhosis, alanine aminotransferase, and proton density fat fraction using Mendelian randomization analysis. Table S13. The associations of HbA1c signal classification in liver steatosis, liver cirrhosis, alanine aminotransferase, and proton density fat fraction using Inverse-variance weighting. Table S14. The associations of iron homeostasis biomarkers in liver steatosis, liver cirrhosis, alanine aminotransferase, and proton density fat fraction using Mendelian randomization analysis. Table S15. The associations of iron homeostasis biomarkers in liver iron using Mendelian randomization analysis. Table S16. The associations of liver iron in liver steatosis, liver cirrhosis, alanine aminotransferase, and proton density fat fraction using Mendelian randomization analysis. Table S17. The associations of HbA1c signal classification in iron homeostasis biomarkers and liver iron using Inverse-variance weighting.