Urinary 8-oxo-7,8-dihydroguanosine levels are elevated in HCV-infected patients

HCV patients are usually under substantial oxidative stress because of viral infection. A total of 177 patients with HCV infection and 198 age- and sex-matched healthy controls were enrolled in this study. We evaluated the urinary levels of 8-oxo-7, 8-dihydro-2’deoxyguanosine (8-oxodGuo) and 8-oxo-7, 8-dihydroguanosine (8-oxoGuo) in patients with HCV infection and explored the factors affecting the urinary 8-oxodGuo or 8-oxoGuo levels. Biomarkers of liver function, cancer, and inflammation were determined. Nonparametric correlations were used to evaluate the correlation between 8-oxoGuo or 8-oxodGuo and various laboratory biochemical indicators. Results showed that the levels of urinary 8-oxoGuo both in male and female patients with HCV infection were significantly higher than those in healthy controls (both p Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1961272 .

丙型肝炎病毒（Hepatitis C Virus，HCV）感染患者通常因病毒感染而处于显著的氧化应激状态。本研究共纳入177例HCV感染患者与198例年龄、性别匹配的健康对照个体。我们对HCV感染患者尿液中的8-氧代-7,8-二氢-2'-脱氧鸟苷（8-oxo-7,8-dihydro-2’deoxyguanosine，8-oxodGuo）与8-氧代-7,8-二氢鸟苷（8-oxo-7,8-dihydroguanosine，8-oxoGuo）水平进行了检测，并探讨了影响尿液中8-oxodGuo或8-oxoGuo水平的相关因素。同时测定了肝功能、肿瘤及炎症相关生物标志物。采用非参数相关性分析评估8-oxoGuo或8-oxodGuo与各类实验室生化指标间的相关性。结果显示，无论男性还是女性HCV感染患者，其尿液中8-oxoGuo水平均显著高于健康对照（两组p值均）。本文补充数据可通过https://doi.org/10.1080/15257770.2021.1961272在线获取。