脯氨酸的原始数据提示血清杀伤 KP.xlsx

这项研究表明，脯氨酸是一种有效的代谢物，通过通量进入丙酮酸/TCA 循环，在体外和体内逆转肺炎克雷伯菌血清耐药性，丙酮酸/TCA 循环上调补体结合蛋白和 PMF 的表达，允许形成 MAC，最终导致细胞死亡。

This study demonstrates that proline, an effective metabolite that enters the pyruvate/TCA cycle via metabolic flux, reverses the serum resistance of Klebsiella pneumoniae both in vitro and in vivo. The pyruvate/TCA cycle upregulates the expression of complement-binding proteins and PMF, allowing the formation of MAC and ultimately leading to cell death.