Survival data and virulence analysis of Rhizopus microsporus strains in a murine infection model

This dataset contains virulence assay data from Rhizopus microsporus strains in a murine infection model. Male Swiss mice (30 g, one month old) were infected by retroorbital injection with 1 × 10⁶ sporangiospores per animal from different R. microsporus strains (ATCC11559, UM6, UM33, UM120). The Excel file includes two sheets: Virulence Data: individual survival data by mouse, with time to death expressed as days post-infection (DPI). Each column corresponds to a fungal strain, with values indicating survival outcome (1 = death, 0 = alive at endpoint). Log-rank (Mantel–Cox) test: statistical analysis comparing Kaplan–Meier survival curves between strains, including chi-square values, degrees of freedom, p-values, and significance summary. These data support Kaplan–Meier survival analyses used to evaluate virulence differences among R. microsporus strains in vivo. These processed data analyses reported in the manuscript “Phosphatidylcholine Biosynthesis via ChoC is Crucial for Cellular Integrity and Virulence in Rhizopus microsporus”.本数据集包含小鼠感染模型中微小根毛霉（Rhizopus microsporus）菌株的毒力测定数据。选取体重30g、月龄1个月的雄性瑞士小鼠，经眶后注射（retroorbital injection）攻毒接种不同微小根毛霉菌株（ATCC11559、UM6、UM33、UM120）的孢囊孢子（sporangiospores），每只动物接种1×10⁶个。 该Excel文件包含两个工作表： Virulence Data（毒力数据）：单只小鼠的存活数据，死亡时间以感染后天数（days post-infection, DPI）表示；每一列对应一株真菌菌株，单元格数值代表存活结局（1=小鼠死亡，0=实验终点时仍存活）。 Log-rank (Mantel–Cox) test（对数秩检验（Log-rank (Mantel–Cox) test））：用于比较不同菌株间Kaplan–Meier生存曲线（Kaplan–Meier survival curves）的统计学分析，包含卡方值、自由度、p值及显著性总结。 上述数据可用于支撑评估体内微小根毛霉菌株间毒力差异的Kaplan–Meier生存分析。本数据集的经处理数据分析已发表于论文《磷脂酰胆碱经ChoC介导的生物合成对微小根毛霉的细胞完整性与毒力至关重要》（Phosphatidylcholine Biosynthesis via ChoC is Crucial for Cellular Integrity and Virulence in Rhizopus microsporus）。