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Total Synthesis of Chaetoquadrins A–C

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NIAID Data Ecosystem2026-03-07 收录
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The first total synthesis of the monoamine oxidase inhibitors chaetoquadrins A–C has been accomplished. Key steps in the synthesis include an aromatic Claisen rearrangement, asymmetric boron aldol reaction and acid-mediated spiroketalization. Comparison of spectral data for the synthetic spiroketals confirmed the proposed structure for these natural products.

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2013-02-01
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