Raw Data and Analysis by Skyline
收藏中国科技资源共享网2026-04-13 更新2026-04-04 收录
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https://escience.org.cn/metadata/detail?cstrId=CSTR:17970.11.A001G.202003.000831&id=774e74221ac511e980780242ac120006:CSTR:A0006.11.A001G.202003.000831
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资源简介：
Type 2 diabetes (T2D) is a major chronic healthcare concern worldwide. Emerging evidence suggests that a histone-modification-mediated epigenetic mechanism underlies T2D. Nevertheless, the dynamics of histone marks in T2D have not yet been carefully analyzed. Using a mass spectrometry-based label-free and chemical stable isotope labeling quantitative proteomic approach, we systematically profiled liver histone post-translational modifications (PTMs) in a prediabetic high-fat diet-induced obese (DIO) mouse model. We identified 170 histone marks, 30 of which were previously unknown. Interestingly, about 30% of the histone marks identified in DIO mouse liver belonged to a set of recently reported lysine acylation modifications, including propionylation,
提供机构：
国家人口健康科学数据中心
创建时间：
2020-11-24
