Supplementary Material for: JAK 2 positive diseases and spontaneous coronary artery dissection (SCAD): Case Series

Introduction
Chronic myeloproliferative neoplasms such as polycythaemia vera (PV) and essential thrombocytosis (ET) are associated with atherosclerosis and cardiovascular events. Especially if JAK2 mutation is there. In rare cases, also spontaneous coronary artery dissection (SCAD) can be seen.
Case Presentation
This case series describe two case reports of myeloproliferative neoplasms in which spontaneous coronary artery dissection (SCAD) was found in both of them in addition to standard atherosclerosis. First one was about a 42-year-old man who was admitted as acute myocardial infarction (MI) then found to have polycythaemia vera and SCAD. The second one was about a 52-year-old man, also admitted as acute MI, then found to have SCAD and essential thrombocythemia. JAK2V617F missense mutation was found in both cases.
Conclusion
Myeloproliferative neoplasms with JAK2 mutations are associated with spontaneous coronary artery dissection in addition to usual atherosclerosis. This association needs further research.

引言
慢性骨髓增殖性肿瘤（chronic myeloproliferative neoplasms）如真性红细胞增多症（polycythaemia vera, PV）与原发性血小板增多症（essential thrombocytosis, ET），可与动脉粥样硬化及心血管事件相关，尤其当存在JAK2突变时。在罕见情况下，还可出现自发性冠状动脉夹层（spontaneous coronary artery dissection, SCAD）。
病例报告
本病例系列纳入2例骨髓增殖性肿瘤病例，两例均在确诊动脉粥样硬化的基础上检出自发性冠状动脉夹层（SCAD）。第一例为42岁男性，因急性心肌梗死（acute myocardial infarction, MI）入院，后续确诊真性红细胞增多症合并SCAD。第二例为52岁男性，同样因急性心肌梗死入院，后续确诊SCAD合并原发性血小板增多症。两例均检出JAK2V617F错义突变。
结论
携带JAK2突变的骨髓增殖性肿瘤患者，除常规动脉粥样硬化风险外，还与自发性冠状动脉夹层存在关联。该关联仍需开展进一步研究。