Two new cyclic dipeptides from Rhinocladiella sp. lgt-3, a fungal endophyte isolated from Tripterygiun wilfordii Hook

Two new cyclic dipeptides, rhinocladin A (1) and rhinocladin B (2), were isolated from a fungal endophyte (Rhinocladiella sp. lgt-3) of Tripterygiun wilfordii Hook. Their structures were elucidated by 1D and 2D NMR spectra. The monoamine oxidase inhibitory activity of 1 and 2 was also evaluated.本研究从雷公藤（Tripterygiun wilfordii Hook.）的真菌内生菌Rhinocladiella sp. lgt-3中分离得到两个新型环二肽类化合物：rhinocladin A（1号）与rhinocladin B（2号）。通过一维（1D）与二维（2D）核磁共振（Nuclear Magnetic Resonance, NMR）谱图对二者的结构进行了解析，同时还对化合物1与2的单胺氧化酶抑制活性进行了评价。