Enantioselective Nickel-Catalyzed Hydrocyanative Desymmetrization of Norbornene Derivatives

A nickel-catalyzed enantioselective hydrocyanation of N-aryl 5-norbornene-endocis-2,3-dicarboximides was reported. This desymmetrization process allows for a quick construction of both continuous stereogenic carbon centers and remote N–CAr atropisomeric chirality. Mechanism studies indicated that the resident carbonyl group of the substrates plays a key role in the enantioselectivity.本研究报道了一种镍催化的N-芳基-5-降冰片烯-内顺-2,3-二甲酰亚胺对映选择性氢氰化反应。该去对称化过程可快速构建连续手性碳中心与远程N–CAr轴手性结构。机理研究表明，底物的固有羰基基团对对映选择性具有关键作用。