Transcription events constructed by txrevise

List of pre-computed transcription events constructed by txrevise. See the txrevise home page for more details: https://github.com/kauralasoo/txrevise. If you use txrevise in your research, please cite the following paper: Alasoo, Kaur, et al. "Genetic effects on promoter usage are highly context-specific and contribute to complex traits." Elife 8 (2019): e41673 We have constructed two types of events. In the main event files we have masked the alternative internal exons in the promoter and 3' end events (labeled upstream and downstream). This ensures that we can reliably distinguish promoter usage and 3' end usage from alternative splicing, which are likely to be driven by distinct molecular mechanisms. The main annotation files are: Homo_sapiens.GRCh37.87.version_1.tar.gz Homo_sapiens.GRCh38.92.version_1.tar.gz Homo_sapiens.GRCh38.96.version_1.tar.gz We have also constructed an alternative set of "raw" annotation files where the alternative internal exons in promoter and 3' end events have not masked. This maximises QTL discovery, because we can now also detect splicing event near promoters and 3 ends, but it comes at the expense that we are no longer able to distinguish between different molecular mechanisms. The raw annotation files are: Homo_sapiens.GRCh37.87.raw_events.version_1.tar.gz Homo_sapiens.GRCh38.92.raw_events.version_1.tar.gz本数据集为txrevise构建的预计算转录事件（pre-computed transcription events）列表。如需了解更多细节，请访问txrevise官方主页：https://github.com/kauralasoo/txrevise。若您在研究工作中使用txrevise，请引用以下论文：Alasoo, Kaur, et al. "Genetic effects on promoter usage are highly context-specific and contribute to complex traits." Elife 8 (2019): e41673 我们构建了两类事件集。在主事件文件中，我们对启动子与3'端（3' end）事件（分别标记为上游事件与下游事件）内的可变内部外显子（alternative internal exons）进行了屏蔽处理。此举可确保我们能够可靠地区分启动子使用（promoter usage）、3'端使用事件与可变剪接（alternative splicing）事件——后者通常由不同的分子机制所驱动。主注释文件如下： Homo_sapiens.GRCh37.87.version_1.tar.gz Homo_sapiens.GRCh38.92.version_1.tar.gz Homo_sapiens.GRCh38.96.version_1.tar.gz 此外，我们还构建了另一套“原始”注释文件集，其中未对启动子与3'端事件内的可变内部外显子执行屏蔽操作。该配置可最大化数量性状位点（Quantitative Trait Locus, QTL）的发现效率，因为我们现在能够检测启动子与3'端附近的剪接事件，但代价是无法再区分不同的分子机制。原始注释文件如下： Homo_sapiens.GRCh37.87.raw_events.version_1.tar.gz Homo_sapiens.GRCh38.92.raw_events.version_1.tar.gz