An Approach to 3‑(Indol-2-yl)succinimide Derivatives by Manganese-Catalyzed C–H Activation

The manganese-catalyzed addition of C-2 position of indoles to maleimides has been achieved under additive-free conditions. The manganese catalyst exhibits excellent chemo- and regioselectivity, good functional group compatibility, and high catalytic efficiency. The substrate scope can also be extended to maleates, ethyl acrylate, 1,4-dihydro-1,4-epoxynaphthalene, pyrroles, and 2-phenylpyridine, which further demonstrates the universality of this straightforward approach.本研究成功实现无添加剂条件下，吲哚C-2位与马来酰亚胺在锰催化下的加成反应。该锰催化剂展现出优异的化学选择性与区域选择性、良好的官能团兼容性以及极高的催化效率。该反应的底物范围还可拓展至马来酸酯、丙烯酸乙酯、1,4-二氢-1,4-环氧萘、吡咯以及2-苯基吡啶，进一步验证了该简便方法的普适性。