Trafficking of Francisella within macrophages (A) and amoebae cells (B).

(A) Upon phagocytosis by macrophages, bacteria reside in the FCP that interact with early (EEA1 and Rab 5) and late (Lamps and Rab 7) endocytic compartments. The FCP is rapidly acidified by the vATPase proton pump, resulting in bacterial escape into the cytosol, where it replicates. (B) After phagocytosis by amoebae, bacteria are localized in intact vacuoles. Bacteria reside in the vacuoles and replicate.(A) 当细菌被巨噬细胞（macrophages）吞噬后，将定位于FCP中，该结构可与早期内吞区室（标记分子为EEA1与Rab 5）及晚期内吞区室（标记分子为Lamps与Rab 7）发生相互作用。液泡型ATP酶质子泵（vATPase proton pump）可快速酸化该FCP，促使细菌逃逸至细胞质基质（cytosol）内并进行复制。 (B) 当细菌被阿米巴原虫（amoebae）吞噬后，将定位于完整液泡中，细菌在此类液泡内存活并增殖。