Profile of Chlamydia vaccine research: A bibliometric analysis

Vaccination is the most effective measure to prevent Chlamydia infection. However, to date, no vaccine has successfully completed the rigorous clinical trial process and gained regulatory approval for use in clinical practice. Scholars have been working on a safe and effective Chlamydia vaccine. In order to better grasp, the global frontiers and development trends in this field, a comprehensive bibliometric analysis was carried out. A total of 234 publications closely regarding Chlamydia vaccines were culled from the Web of Science Core Collection database, and the bibliometric information was then extracted with CiteSpace and VOSviewer software. After measurement analysis, the most influential papers were identified in this area, including highly cited papers, references with strong citation burst, and high co-citated papers. Vaccine has published the most literature on Chlamydia vaccines. Only scholars from 39 countries/regions have been engaged in studying Chlamydia vaccines. The USA is the most prolific country and has the highest collaborative strength. The current research area has focused on protective immunity and immunopathological response. Major outer membrane protein (MOMP) is the most common target vaccine antigen. This study reveals the status of literature and highlights emerging trends in this field, which helps researchers seek insights into this area and serve as a reference guide for further investigations.疫苗接种是预防衣原体感染最有效的手段。但迄今为止，尚无一款疫苗能够通过严格的临床试验流程并获得监管机构批准应用于临床实践。学界始终致力于研发安全有效的衣原体疫苗。为全面把握该领域的全球研究前沿与发展趋势，本研究开展了一项综合性文献计量分析。本研究从Web of Science核心合集数据库中筛选得到234篇与衣原体疫苗密切相关的文献，并借助CiteSpace与VOSviewer软件提取文献计量信息。经计量分析后，本研究识别出该领域的高影响力文献，包括高被引论文、强引用突现参考文献以及高共被引论文。《Vaccine》期刊刊载的衣原体疫苗相关文献数量最多。仅有39个国家/地区的学者参与了衣原体疫苗相关研究。美国是该领域发文量最多且合作强度最高的国家。当前该领域的研究热点集中于保护性免疫与免疫病理反应。主要外膜蛋白（Major Outer Membrane Protein，MOMP）是该领域最常用的疫苗靶抗原。本研究厘清了该领域的文献研究现状，并揭示了新兴发展趋势，可为相关领域研究者提供研究视角与参考借鉴，以助力后续探索。