Synthesis of 6‑Phosphorylated Phenanthridines by Mn(II)-Promoted Tandem Reactions of 2‑Biaryl Isothiocyanates with Phosphine Oxides

A novel Mn­(II)-promoted tandem phosphorylation/cyclization reaction of 2-biaryl isothiocyanates with phosphine oxides is described. This is the first general method to synthesize 6-phosporylated phenanthridines from 2-biaryl isothiocyanates. The approach is featured by oxidant-free, low loading of P-reagent, easy operation, and high functional group tolerance.本文报道了一种新颖的二价锰（Mn(II)）介导的2-联芳基异硫氰酸酯（2-biaryl isothiocyanates）与氧化膦（phosphine oxides）的串联磷酸化/环化反应。这是首个由2-联芳基异硫氰酸酯合成6-磷酰化菲啶（6-phosphorylated phenanthridines）的通用方法。该方法具有无氧化剂、磷试剂负载量低、操作简便及官能团耐受性优异等特点。