TFEB and TFE3 are required for efficient cellular response against beta-coronavirus [ChIP-Seq]

The transcription factors EB and E3 (TFEB and TFE3) promote lysosomal biogenesis and autophagy in response to a variety of stress conditions. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the ß-coronaviruses family. Recent studies have shown that ß-coronaviruses use lysosomes to egress the cell. The aim of this work is to analyze if ß-coronavirus infection promotes TFEB/3 activation and to evaluate the contribution of these transcription factors to the cellular response upon viral infection. Analysis of TFE3 binding to promoter of genes under Mouse Hepatitis Virus (MHV) infection in HeLa-mCC1a cells