Handgrip strength as an instrument for assessing the risk of malnutrition and inflammation in hemodialysis patients

Abstract Indroduction: Establishing which parameters to use for diagnosing malnutrition in hemodialysis patients is a challenge in clinical practice. The handgrip strength (HGS) has stood out as a method of assessing nutritional status. Thus, the aim of this study was to determine the cut-off point for HGS in the assessment of the risk of malnutrition and inflammation in HD patients, and its association with other parameters. Methods: Study carried out in hemodialysis units in the city of Curitiba, Brazil. We obtained the cut-off point of the HGS through the ROC curve, using the malnutrition and inflammation score (MIS) as a reference. We checked the relationship (Odds ratio) between the variables “MIS” and “HGS” with the other study variables using the multivariate analysis (logistic regression). Results: We assessed 238 patients (132 men), between 18 and 87 years of age (median = 59). The HGS cut-off point for diagnosing malnutrition and inflammation according to the reference used was摘要与引言：确定血液透析患者营养不良诊断的适宜参数，是临床实践面临的一大难题。握力（handgrip strength, HGS）已成为评估营养状况的重要指标。本研究旨在明确握力在评估血液透析（hemodialysis, HD）患者营养不良与炎症风险中的截断值，并分析其与其他研究变量的关联。 研究方法：本研究于巴西库里蒂巴市的血液透析中心开展。以营养不良炎症评分（malnutrition and inflammation score, MIS）为参照标准，通过受试者工作特征（Receiver Operating Characteristic, ROC）曲线计算得到握力的截断值。采用多变量分析（logistic回归）检验“MIS”与“HGS”两个变量与其余研究变量间的关联（以比值比（Odds ratio）表示）。 研究结果：本研究共纳入238例患者（其中男性132例），年龄范围为18~87岁，中位年龄59岁。基于本次研究所用参照标准，用于诊断营养不良与炎症的握力截断值为