Effects of alcohol on the composition and metabolism of the intestinal microbiota among people living with HIV: a cross-sectional study

Comparison between groups using alpha and beta diversity showed that the diversity of stool microbiota in the drinking group did not differ from that of the non-drinking group (all P>0.05). The Linear discriminant Analysis effect size (LEfSe) algorithm was to determine the bacterial taxa associated with alcohol consumption, and the results showed altered fecal bacterial composition in HIV-infected patients who consumed alcohol, with Coprobacillus, Pseudobutyrivibrio and Peptostreptococcaceae enriched, and Pasteurellaceae and Xanthomonadaceae were depleted. In addition, by using the Kyoto Encyclopedia of Genes and Genomes (KEGG) functional microbiome features were also found to be altered in the drinking group, showing a reduction in metabolic pathways (P=0.036), such as the cardiovascular disease pathway (P=0.006).