Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response_Chowdhary et al.

Raw, unprocessed live cell imaging data for the key Figure 1 of the manuscript "Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response" by Chowdhary et al. These data demonstrate that Hsf1, Mediator, and RNA Pol II form subnuclear clusters upon heat shock. These clusters colocalize in the 3D nuclear space and activate transcription of HSR genes.

本数据集为乔杜里（Chowdhary）等人所撰学术论文《可诱导转录凝聚体驱动热休克应答中的三维基因组重排》（原文标题："Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response"）中关键图1所用的原始未处理活细胞成像（live cell imaging）数据。该数据显示，热休克因子1（Heat Shock Factor 1, Hsf1）、中介体（Mediator）以及RNA聚合酶II（RNA Polymerase II, RNA Pol II）会在热激条件下形成核内亚簇；这些亚簇在三维核空间中共定位，并激活热休克应答（heat shock response, HSR）基因的转录。