RAW DATA for Virulence

The expression of FimH on UPEC may be a key factor affecting the effect of testosterone on the treatment of prostatitis caused by UPEC infection. Whether the JAK/STAT pathway regulates the ability of testosterone to improve inflammation caused by infection with UPEC strains that overexpress FimH remains to be further studied. This is suggested that regulation of the JAK1/STAT3 pathway may be associated with the effects of the FimH virulence factor on the inhibition of testosterone in UPEC infection. The inhibitory effect of testosterone on UPEC infection in prostate epithelial cells was affected by the virulence factor FimH of UPEC, and reduced the production of inflammatory factors. Our study provides a possible guideline for using testosterone to treat recurrent UPEC infection and persistent prostatitis.

尿路致病性大肠杆菌（Uropathogenic Escherichia coli，UPEC）表面FimH的表达，可能是影响睾酮治疗UPEC感染所致前列腺炎疗效的关键因素。Janus激酶/信号转导与转录激活因子通路（JAK/STAT pathway）是否调控睾酮改善过表达FimH的UPEC菌株感染所致炎症的能力，仍有待进一步研究。研究提示，Janus激酶1/信号转导与转录激活因子3（JAK1/STAT3）通路的调控，可能与FimH毒力因子在UPEC感染中对睾酮的抑制作用相关。睾酮对前列腺上皮细胞内UPEC感染的抑制效应，会受到UPEC的FimH毒力因子的影响，同时睾酮可降低炎症因子的生成。本研究为使用睾酮治疗复发性UPEC感染与持续性前列腺炎提供了潜在的指导方向。