Adjuvant radiotherapy may not significantly change outcomes in high-risk cutaneous squamous cell carcinomas with clear surgical margins: A systematic review and meta-analysis

Supplementary Material
I. Table 1- PICOS
II. Table 2- Search Terms for Medline
III. Figure 1. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Flow Diagram: Searching methodology and screening process were utilized to screen and select eligible articles.
IV. Figure 2A-D. Disease-related Outcomes: subanalyses: 2A) All studies excluding those with mostly clear cases (surgery alone=24, surgery and adjuvant radiotherapy=10). 2B) studies with R0 cases only (surgery alone=16, surgery and adjuvant radiotherapy=6). 2C) studies with R0 + unknown margin status cases (surgery alone=24, surgery and adjuvant radiotherapy= 9). 2D) studies that did not include any cases of sentinel lymph node biopsy (SLNB) (surgery alone=24, surgery and adjuvant radiotherapy=11).
V. Table 3- Summary of main analysis and subanalyses- Chi square test

补充材料
I. 表1——PICOS
II. 表2——Medline数据库检索词
III. 图1——系统评价与Meta分析首选报告条目（PRISMA）流程图：采用检索方法与筛选流程对符合条件的文献进行筛选与遴选。
IV. 图2A至D 疾病相关结局：亚组分析：2A） 排除以切缘阴性病例为主的研究（单纯手术组=24，手术联合辅助放疗组=10）；2B） 仅纳入R0切除病例的研究（单纯手术组=16，手术联合辅助放疗组=6）；2C） 纳入R0切除病例及切缘状态未知病例的研究（单纯手术组=24，手术联合辅助放疗组=9）；2D） 未纳入前哨淋巴结活检（SLNB）病例的研究（单纯手术组=24，手术联合辅助放疗组=11）。
V. 表3——主分析与亚组分析汇总——卡方检验