List of the candidate genes found for 81 OMIM loci with unknown molecular basis.

The column ‘status’ reviews the current knowledge about the association of the candidate with the disease. In particular, 1 = gene not previously associated with the disease; 2 = gene involved in mendelian phenotype sharing a MimMiner similarity score of 0.4 or higher with the phenotypic description of the locus; 3 = gene previously considered as a candidate for clinical similarity, but with a MimMiner similarity score to the locus lower than 0.4. Moreover, genes annotated with “#” represent the actual disease gene, because mutations have been found in patients; genes annotated with “£” have been excluded by refining the map interval; genes annotated with “*” could be excluded because mutations have been found in a different gene of the same locus; genes annotated with “$” are at the moment excluded because they have been screened but no mutations considered to be relevant have been found. The above statements are supported by the indicated references: i = [38]; ii = [39]; iii = [40]; iv = [41]; v = [42]; vi = [43]; vii = [44]; viii = [45]; ix = [46]; x = [47]; xi = [48]; xii = [49]. The column “Net.” indicates the networks from which the candidate was predicted: A = Affy; S = Stanford.