Maternal Folic Acid Supplementation and Dietary Folate Intake and Congenital Heart Defects

It has been reported that folic acid supplementation before and/or during<br>pregnancy could reduce the risk of congenital heart defects (CHDs). However, the<br>results from limited epidemiologic studies have been inconclusive. We investigated the<br>associations between maternal folic acid supplementation, dietary folate intake, and<br>the risk of CHDs

已有研究表明，在孕前及/或孕期补充叶酸（folic acid supplementation）可降低先天性心脏缺陷（congenital heart defects, CHDs）的发病风险。然而，现有有限的流行病学研究结果尚无定论。
本研究探究了孕产妇叶酸补充、膳食叶酸摄入与先天性心脏缺陷发病风险之间的关联。