PDB structures of 8,660 type II L-asparaginases from bacteria and archaea

This dataset contains predicted protein structures of 8,660 type II L-asparaginase (AII) sequences from bacteria and archaea. Structures were generated using AlphaFold2 v2.2.3 with the multimer setting enabled to model homotetrameric assemblies, reflecting the typical quaternary structure of functional L-asparaginases. These structural models were used to investigate the diversity and potential therapeutic relevance of type II L-asparaginases, including identification of enzymes with no detectable L-glutaminase activity. The dataset supports the findings of the publication:Janicki M. et al. A new bacterial L-asparaginase with no L-glutaminase activity: a promising candidate for leukemia therapy.本数据集包含来自细菌与古菌的8660条II型L-天冬酰胺酶（type II L-asparaginase，AII）序列的预测蛋白质结构。这些结构通过AlphaFold2 v2.2.3版本生成，启用多聚体建模模式以构建同源四聚体组装体，契合功能性L-天冬酰胺酶的典型四级结构特征。 这些结构模型被用于探究II型L-天冬酰胺酶的多样性及其潜在治疗相关性，其中还鉴定出无可检测L-谷氨酰胺酶（L-glutaminase）活性的酶类。 本数据集佐证了下述论文的研究结论：Janicki M. 等人发表的《一种无L-谷氨酰胺酶活性的新型细菌L-天冬酰胺酶：白血病治疗的极具潜力的候选药物》。