Reductive CO2 Fixation via Tandem C–C and C–N Bond Formation: Synthesis of Spiro-indolepyrrolidines

We describe herein a tandem C–C and C–N bond-forming reaction in the reductive functionalization of CO2, an abundant and cheap C1 chemical feedstock. This catalytic metal-free CO2 fixation afforded spiro-indolepyrrolidines by dearomatization of tryptamine derivatives with broad scope and good functional group tolerance under mild conditions.本文报道了一种以丰富廉价的C1化工原料二氧化碳为底物的还原官能化反应中的串联C-C与C-N成键过程。该无金属催化的二氧化碳固定反应可在温和条件下，通过色胺衍生物的去芳构化反应，得到兼具广谱底物适用性与优良官能团耐受性的螺吲哚吡咯烷类化合物。