IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2329 proposal and can be grouped in different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some teams are dedicated to serial crystallography and its developments, for which the ESRF-EBS has become the perfect tool.

本提案中的IBS BAG涵盖IBS内部研究团队，以及来自格勒诺布尔iRTSV/CEA、卡达拉什CEA（圣保罗莱迪朗斯）和布勒蒂尼叙尔奥尔格IRBA的外部合作课题组。本团队聚焦蛋白质结构与功能的关联研究，重点覆盖人类健康、生物技术及研究方法学三大方向。本项目绝大多数为MX-2329提案的延续，可划分为如下多个研究主题：宿主-病原体互作、全新药物靶点、基础细胞机制、膜蛋白、内在无序蛋白质、生物技术应用以及研究方法学。部分项目采用整合研究策略，包含X射线晶体学（X-ray crystallography）、小角X射线散射（SAXS）、核磁共振（NMR）与冷冻电镜（cryo-EM），并辅以其他生物物理研究手段，旨在全面解析所研究的生物大分子系统的复杂性。另有部分团队致力于串行晶体学及其技术发展，欧洲同步辐射装置-增强型束流线（ESRF-EBS）已成为该领域的绝佳研究工具。