TARGET and expanded access trials.

Abbreviations: AE = adverse event; CI = confidence interval; CR = complete response; ECOG PS = Eastern Cooperative Oncology Group performance status; HFSR = hand-foot skin reaction; HR = hazard ratio; MSKCC = Memorial Sloan Kettering Cancer Center; NE = estimable; NR = not reported; OS = overall survival; PBO = placebo; PFS = progression-free survival; PR = partial response; SAE = serious adverse event; SD = stable disease.a Unless otherwise specified, refers to entire study population.b Data missing for 36 pts.c Data missing for 2 pts.d Data missing for 5 pts.e Eligibility criteria included ECOG PS 0–2 with waivers granted to selected pts with PS 3 or 4.f n = 1891.g Considered treatment related.h All reported AEs were considered treatment related.TARGET and expanded access trials.