Prevalence characteristics of cervical human papillomavirus (HPV) genotypes in the Taizhou area, China: a cross-sectional study of 37 967 women from the general population

Objectives: High-risk human papillomaviruses (hrHPVs) are highly prevalent worldwide, and HPV genotypes differ between geographical regions; however, sexually transmitted HPV may lead to cervical carcinogenesis. The objective of this cross-sectional study was to estimate the prevalence characteristics of cervical HPV genotypes in Taizhou, Southeast China.

Setting and participants: A population-based sample of 37 967 eligible women (median age: 41.6; range: 15–90 years) visiting the Taizhou ENZE Medical Center in Taizhou (2012–2016) was analysed. HPV genotyping was performed on the collected specimens using a GP5+/bioGP6+-PCR/MPG assay by Luminex 200, which simultaneously identifies 27 different HPV genotypes and the β-globin gene (internal control).

Results: The overall HPV infection rate was 22.8% in the Taizhou-based population, and the prevalence of high-risk HPV, low-risk HPV and mixed high-risk and low-risk HPV infection was 14.2%, 5.7% and 3.0%, respectively. The most preval...

研究背景与目的：高危型人乳头瘤病毒（hrHPVs）在全球范围内流行率极高，且不同地理区域的HPV基因型分布存在差异；经性传播的HPV可引发宫颈癌变。本横断面研究旨在明确中国东南部台州地区宫颈HPV基因型的流行特征。
研究对象与场景：本研究纳入2012-2016年间就诊于台州恩泽医疗中心（Taizhou ENZE Medical Center）的37967名符合入组标准的女性作为基于人群的研究样本，其年龄中位数为41.6岁，年龄范围为15~90岁。采集受试者标本后，采用Luminex 200平台结合GP5+/bioGP6+-PCR/MPG检测法进行HPV基因分型，该方法可同时鉴定27种不同的HPV基因型及作为内参的β-珠蛋白基因（internal control）。
研究结果：台州地区人群总体HPV感染率为22.8%，其中高危型HPV、低危型HPV以及高危与低危混合型HPV的感染率分别为14.2%、5.7%和3.0%。最常见的流行...