Cellular Origins and Genetic Landscape of Cutaneous GD T Cell Lymphoma

Cutaneous gamma-delta T cell lymphomas are a rare and aggressive subtype of cutaneous lymphoma. In the present study, we analyzed these cancers by DNA and RNA sequencing in order to illuminate the genetic landscape for this rare disease. We obtained tumor samples from multiple institutions, including Northwestern University (Chicago, IL), University of Chicago (Chicago, IL), University of Virginia (Charlottesville, VA), and Massachusetts General Hospital (Boston, MA).]]> Patients were included in this study if they carried a clinical diagnosis of primary cutaneous lymphoma, with gamma-delta T cell receptor expression confirmed by either immunohistochemistry and/or next generation sequencing.]]> Tissue samples were obtained from patients at Massachusetts General Hospital and University of Virginia Health System from 2014-2015. Tissue samples were collected from patients at Northwestern Memorial Hospital beginning in 2015 through 2019. Tissue samples were collected at University of Chicago in 2015. DNA/RNA isolation and sequencing was performed in 2019.]]>