Various PubChem lists for Parkinson's Disease and related disorders

Collection of 8 lists of chemicals associated to Parkinson's disease (PD) and related disorders. PubChem functionality relating Medical Subject Headings (MeSH) information on certain disease endpoints to chemicals was explored to create the lists. The following table describes the mentioned lists. Name Description PD-MetFrag MetFrag database of 21,303 chemicals related to PD, PD Secondary, Parkinsonian disorders, Lewy body disease, Alzheimer disease, dementia, Huntington disease and neurodegenerative disorders PD-CTD List of 296 chemicals associated to PD in the Comparative Toxicogenomic Database (CTD), extracted via the CTD integration within PubChem D003248 List of 3,943 chemicals related to Constipation Disorders D000857 List of 688 chemicals related to Olfactory Impairment D003863 List of 363 chemicals associated to Depression Disorders D001008 List of 8,433 chemicals associated to Anxiety Disorders D020920 List of 59 chemicals related to Dyssomnias D012893 List of 2,781 chemicals associated to Sleep Wake Disorders Further details can be found in the published manuscript (https://doi.org/10.1007/s00216-022-04207-z).本数据集包含8组与帕金森病（Parkinson's disease, PD）及相关病症相关的化学物质集合。研究借助PubChem的相关功能，将特定疾病终点对应的医学主题词表（Medical Subject Headings, MeSH）信息与化学物质进行关联，以此构建了上述8组化学物质列表。下表对各列表的名称与描述进行说明： - PD-MetFrag：涵盖21303种与帕金森病、继发性帕金森病、帕金森综合征、路易体痴呆、阿尔茨海默病、痴呆、亨廷顿舞蹈症及神经退行性疾病相关的化学物质的MetFrag数据库 - PD-CTD：通过PubChem集成的比较毒理基因组学数据库（Comparative Toxicogenomic Database, CTD）提取得到的296种与帕金森病相关的化学物质列表 - D003248：包含3943种与便秘障碍相关的化学物质列表 - D000857：包含688种与嗅觉障碍相关的化学物质列表 - D003863：包含363种与抑郁障碍相关的化学物质列表 - D001008：包含8433种与焦虑障碍相关的化学物质列表 - D020920：包含59种与睡眠障碍相关的化学物质列表 - D012893：包含2781种与睡眠-觉醒障碍相关的化学物质列表 更多详细信息可参阅已发表的学术论文（https://doi.org/10.1007/s00216-022-04207-z）。