Dataset related to article "Rheumatoid factor and anti-citrullinated peptide antibodies in the general population: hepatitis B and C virus association and 15-year-risk of rheumatoid arthritis "

This record contains data related to the article "Rheumatoid factor and anti-citrullinated peptide antibodies in the general population: hepatitis B and C virus association and 15-year-risk of rheumatoid arthritis". <strong>Objectives: </strong> The study aimed to determine the prevalence of rheumatoid factor (RF) and anti-citrullinated peptides (ACPA), to estimate the association with hepatitis B (HBV) or C (HCV) virus infections and the 15-year risk of developing RA in a large cohort from a Northern Italian region. <strong>Methods: </strong> In 1998, 15,907 subjects between the ages of 18 and 75 were randomly selected 1:4 for HBV and HCV testing; more recently, we tested a subgroup of sera for RF (n=2196) and ACPA (n=2525). Administrative databases were searched after 15 years for incident RA diagnoses occurring between 1998 and 2013. <strong>Results: </strong> RF was positive in 8.1% of cases with 10% of RF-positive subjects having HBsAg (p=0.004) and 9% anti-HCV. ACPA were detected in 4.8% of subjects with 5% of the ACPA-positive subjects having HBsAg and 5.9% anti-HCV. Older subjects had higher positivity rates for both RF and ACPA. HBsAg and anti-HCV were detected in 5.5% and 4.3% of sera, respectively. Over 15 years, 10 RA cases were recorded (9 women, median age at diagnosis 52 years) with RF previously positive in 2/10 and ACPA in 5/10 cases. RF and ACPA were associated with relative risks for developing RA of 5.7 (adjusted for HBsAg status; 95% CI 1.2-26.3) and 13.2 (95% CI 3.8-46.3), respectively. <strong>Conclusions: </strong> Our data in a large cohort from an unselected general population confirm a higher risk of RA development associated with ACPA compared to RF. HBV exposure correlates with RF but not with ACPA positivity.本数据集收录了与题为《普通人群中类风湿因子与抗瓜氨酸化肽抗体：乙型、丙型肝炎病毒关联及类风湿关节炎15年发病风险》的研究论文相关的数据。**研究目的**：本研究旨在针对意大利北部某地区的大型队列人群，明确类风湿因子（RF）与抗瓜氨酸化肽抗体（ACPA）的检出率，评估其与乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）感染的关联，并分析罹患类风湿关节炎（RA）的15年发病风险。**研究方法**：1998年，研究人员按1:4的比例随机选取15907名年龄介于18至75岁的受试者，开展HBV与HCV检测；近期，研究人员又对其中的血清亚组样本进行了RF检测（n=2196）与ACPA检测（n=2525）。在随访满15年后，通过行政数据库检索1998年至2013年间新发的RA确诊病例。**研究结果**：RF阳性率为8.1%，其中10%的RF阳性受试者呈乙型肝炎表面抗原（HBsAg）阳性（p=0.004），9%呈抗丙型肝炎病毒抗体（anti-HCV）阳性。ACPA阳性率为4.8%，其中5%的ACPA阳性受试者呈HBsAg阳性，5.9%呈抗-HCV阳性。年龄较高的受试者RF与ACPA的阳性率均更高。血清样本中HBsAg与抗-HCV的检出率分别为5.5%与4.3%。15年随访期间共记录到10例RA新发确诊病例（9例为女性，诊断时中位年龄为52岁），其中2例的既往RF检测结果为阳性，5例的既往ACPA检测结果为阳性。RF与ACPA对应的RA发病相对风险分别为5.7（经HBsAg状态校正，95%置信区间：1.2~26.3）与13.2（95%置信区间：3.8~46.3）。**研究结论**：本研究基于未经筛选的普通人群大型队列数据，证实相较于RF，ACPA与RA发病风险升高的关联更为显著。HBV暴露与RF阳性存在相关性，但与ACPA阳性无关联。