CHRONIC NEUTROPENIA REVEALING HYPER IGM SYNDROME: A CASE REPORT

Hyper IgM syndrome is a well-knownhereditaryimmunodeficiency, first describedin 1961. It iscaused by a defect in B lymphocytes, characterized by a normal or high serumlevel of IgM and a low or zerolevel of IgG, IgA, IgE resultingfrom a deficiency in isotype switching. Itsclinical manifestations are dominated by recurrent infections, especiallyrespiratory and digestive. The interest of this article is to illustrate a particular mode of revelation of hyper IgM syndromes through persistent chronicneutropenia in an infant.