EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifically expressed in Ewing’s sarcoma family tumors (ESFT) and is thought to be the initiating event in
A673 Ewing sarcoma cells were transfected with siRNAs targeting ZEB2 (siZEB2-5 and siZEB2-6) or a control siRNA (siControl) and RNAseq was performed to identify ZEB2 regulated genes in Ewing sarcoma.