Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative That Increases Receptor Resonance Time in the Nucleus of Breast Cancer Cells

Protein Data Bank Japan2023-10-18 更新2026-04-19 收录

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Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative That Increases Receptor Resonance Time in the Nucleus of Breast Cancer Cells Descriptor: (5R,6S)-5-(4-{2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol, Estrogen receptor Authors: Hosfield, D.J, Greene, G.L, Fanning, S.W. Deposit date: 2022-03-31 Release date: 2022-06-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022

与甲基化拉索昔芬衍生物结合的雌激素受体α（Estrogen Receptor Alpha）配体结合域：该衍生物可延长乳腺癌细胞核内受体的共振时间描述物：(5R,6S)-5-(4-{2-[(2R)-2-甲基吡咯烷-1-基]乙氧基}苯基)-6-苯基-5,6,7,8-四氢萘-2-醇、雌激素受体作者：Hosfield, D.J.、Greene, G.L.、Fanning, S.W. 提交日期：2022年3月31日发布日期：2022年6月15日最后修改日期：2023年10月18日实验方法：X射线衍射（1.8埃）引用文献：立体特异性拉索昔芬衍生物揭示ESR1突变乳腺癌细胞中雌激素受体α的稳定性与拮抗活性之间的相互作用。《eLife》，第11卷，2022年

创建时间：

2022-03-31