Antimalarial test data

Background Malaria, despite progresses, is still causing huge number of malaria cases and deaths. Successful control of this disease demands the availability of drugs with high efficacy and minimal toxicity. In addition to modern medicines, traditional medicinal plants have long been used for managing malaria. However, many of these medicinal plants are not scientifically validated. Objective This study was conducted to assess the invivo antimalarial activity of Zehneria scabra, against Plasmodium berghei in swiss albino mice. Materials and methods Maceration technique has been used to extract the plant, and four doses of the extract ranging from 25-150 mg/kg were used. Tween 80 was used as negative control, and chloroquine was used a standard drug. The level of parasitemia and malaria-related variations including, packed cell volume, survival time, temperature and body weight were measured, and these records were used to weigh the extract-treated groups against both controls. Res..., A plant material was collected and authenticated. The plant was extracted using maceration. The extract was tested for its antimalarial activity using three models: four-day suppressive test, Ranes test and prophylactic test. The data was then analyzed using the SPSS. , ,研究背景：尽管疟疾防控已取得一定进展，但目前仍造成大量感染病例与死亡病例。对该疾病的成功防控，有赖于获得高疗效、低毒性的抗疟药物。除现代药物外，传统药用植物长期以来被用于疟疾的治疗，但其中多数尚未经过科学验证。 研究目的：本研究旨在评估糙籽栝楼（Zehneria scabra）提取物对瑞士白化小鼠体内（in vivo）伯氏疟原虫（Plasmodium berghei）的抗疟活性。 材料与方法：本研究采用浸渍法提取该植物提取物，并设置25~150 mg/kg共4个剂量梯度的提取物给药组。以吐温80（Tween 80）作为阴性对照，以氯喹（chloroquine）作为阳性标准对照药物。检测各组小鼠的虫血症水平，以及与疟疾相关的指标变化，包括红细胞压积、存活时间、体温与体重，并通过上述检测结果对比提取物给药组与两类对照组的差异。此外，采集并鉴定了植物原材料，采用浸渍法完成提取。通过4天抑制试验、Rane试验与预防性试验三种模型评估提取物的抗疟活性，并采用SPSS统计软件对实验数据进行分析。