Microscopic Colitis single-cell RNAseq

Patients with microscopic colitis, chronic diarrhea without histologic signs of microscopic colitis, or unaffected controls were profiled using single-cell RNA sequencing. T-cell receptor sequencing was also performed on a subset of patients. A combination of 10X genomics and inDrops technologies were used. Individual transcriptomes were analyzed to characterize the cellular profile associated with microscopic colitis and search for mediators of disease pathology. This page contains the processed data; code for processing inDrops reads and for generating the publication figures can be found in the Zenodo archive of our GitHub repository (10.5281/zenodo.14990696).本研究对显微镜下结肠炎（microscopic colitis）患者、无显微镜下结肠炎组织学特征的慢性腹泻患者，以及健康对照个体开展了单细胞RNA测序（single-cell RNA sequencing）分析；同时对部分亚组患者进行了T细胞受体测序（T-cell receptor sequencing）。实验采用10X Genomics与inDrops技术联用的方案。通过对单个转录组进行分析，本研究旨在解析与显微镜下结肠炎相关的细胞特征，并探寻疾病病理的介导因子。本页面包含已预处理完成的测序数据；用于处理inDrops测序读段以及生成发表论文配图的代码，可在本团队GitHub仓库的Zenodo存档（10.5281/zenodo.14990696）中获取。