Effect of 3-BrPA on reversing ABCB-1/P-gp mediated drug resistance in MCF-7 and MCF-7/ADR.

Cell survival was determined by MTT assay as described in Materials and Methods.aData in the table are shown as the means ± SD (n = 6) of at least three independent experiments.bRR value indicating the fold reversal of MDR.**PP50 versus that absence of 3-BrPA.#P50 versus that VRP.Effect of 3-BrPA on reversing ABCB-1/P-gp mediated drug resistance in MCF-7 and MCF-7/ADR.细胞存活率采用材料与方法中记载的MTT比色法（MTT assay）测定。 注a：表格中数据以至少3次独立实验的平均值±标准差（SD，Standard Deviation）呈现，每组n=6。 注b：RR值代表多药耐药（MDR，Multidrug Resistance）的逆转倍数。**与未添加3-溴丙酮酸（3-BrPA）组相比，P<0.05；#与长春新碱（VRP，Vincristine）组相比，P<0.05。 3-溴丙酮酸（3-BrPA）对MCF-7及MCF-7/ADR细胞中ABCB-1/P-糖蛋白（P-gp，P-glycoprotein）介导的多药耐药的逆转作用。