Drug metabolizing enzyme variants.

*CYP2C9 genotypes checked and ruled out: *2, *3, *5, *8, *9, *10, *11, *12, *18; absence of these alleles defaults to *1.
†CYP2C19 genotypes based on single defining SNPs for the *17 and *2 alleles; all other alleles ruled out by default.
‡The in vivo phenotype for the combination of an increased activity allele and a loss-of-function allele for CYP2C19 is not well studied to date. According to Scott et al [53], one paper has reported intermediate activity for this allele combination with respect to clopidogrel, but the study was not replicated and therefore the phenotype is considered provisional. The actual phenotype associated with this combination may vary depending upon other factors such as the medication(s) the patient is taking, as well as other inducers and inhibitors of CYP2C19.
§CYP2D6 genotypes checked: *2, *4, *5, *10, *15, *8, *11, *12, *14, *17, *19, *20, *29, *31, *35, *40, *41, *69; absence of these alleles defaults to *1.