Regioselective Intermolecular [2 + 2]-Cycloaddition of α‑Iodo-Unsaturated Ketones Promoted by Diisobutylaluminum Hydride

The development of intermolecular [2 + 2]-cycloaddition of α-iodo-unsaturated ketones in the presence of diisobutylaluminum hydride (Dibal-H) is reported to produce various trispirocyclic derivatives containing a cyclobutane ring. This sequential lactonization/[2 + 2]-cycloaddition proceeds in high regioselectivity under mild conditions.