Next Generation Sequencing Facilitates Quantitative Analysis of C57BL/6J mice.
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https://www.ncbi.nlm.nih.gov/sra/SRP270857
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Purpose: Assay for Transposase Accessible Chromatin with high-throughput sequencing (ATAC-seq) is a method for mapping chromatin accessibility genome-wide. The goals of this study are to investigate chromatin accessibility of C57BL/6J mice through ATAC-seq. Results: ATAC-seq reads were aligned to the UCSC mm10 reference genome with BWA-MEM. ATAC-seq peaks were called through MACS2 . Peaks were annotated and known transcription factor binding motifs were further analyzed in the ATAC-seq peaks by HOMER. Overall design: Methods: Dental mesenchymal cells from C57BL/6J mice were process by cell lysis, transposition, and amplification and the DNA libraries were generated by deep sequencing using Illumina NextSeq500.
创建时间：
2020-09-09
