Intratumoral bacteria associate with response to neoadjuvant PD-1 blockade in oral squamous cell carcinoma

Wang et al. applied invasion–adhesion-directed expression sequencing (INVADEseq) to probe the intratumoral microbiome in oral squamous cell carcinoma (OSCC) patients who had been treated with neoadjuvant immunotherapy. Their research revealed that intratumoral bacteria play a significant role in immune activity and the efficacy of immunotherapy, identifying an effective immunotherapy-specific predictor of response for NICB. This underscores the impact of bacterial communities on the interactions of these CD8+ T cells with cDC1, highlighting their importance in immune responses.

Wang等人采用侵袭-黏附定向表达测序（INVADEseq），对接受新辅助免疫治疗的口腔鳞状细胞癌（OSCC）患者的肿瘤内微生物组展开了探究。其研究结果显示，肿瘤内细菌在免疫活性与免疫治疗疗效中发挥关键作用，并鉴定出一种可用于NICB的有效免疫治疗特异性应答预测因子。该研究凸显了细菌群落对CD8+ T细胞与1型常规树突状细胞（cDC1）之间相互作用的影响，进一步强调了其在免疫应答中的重要性。