Rhodium-Catalyzed Asymmetric Ring Opening of Oxabicyclic Alkenes with Sulfur Nucleophiles
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https://figshare.com/articles/dataset/Rhodium_Catalyzed_Asymmetric_Ring_Opening_of_Oxabicyclic_Alkenes_with_Sulfur_Nucleophiles/3345973
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资源简介：
The synthesis of 2-sulfanyl-1,2-dihydro-naphthalen-1-ols is described. This methodology is based on
rhodium catalysis and enables various thiols to undergo an
asymmetric SN2‘ ring opening of oxabenzonorbornadiene.
Under the reaction conditions ([Rh(COD)Cl]2 (2.5 mol %),
(S)-(R)-PPF-PtBu2 (6 mol %), AgOTf (7 mol %), NH4I (1.7
equiv), galvinoxyl (5 mol %), THF, 85 °C), aryl- and alkyl-sulfide adducts are obtained in good to excellent yield and
in high enantiomeric excess (>90% ee).
创建时间：
2004-03-19
