Austrian Crystallographic Diffraction Consortium

The Austrian Crystallographic Diffraction Consortium (ACDC) BAG aims at supporting several macromolecular structural biology groups across Austria (in total
20 research groups at 9 institutions in 4 cities). We employ mainly the technique of X-ray crystallography to characterize macromolecular biological complexes,
but also solution scattering approaches are frequently used to characterize dynamic assemblies. Approval of this BAG will be essential for researchers in all
our groups to carry out their structural studies on various health-related and basic research-oriented topics, which are targeted at characterizing large molecular
assemblies or proteins currently under-represented in the PDB, including membrane proteins. Corresponding high-resolution diffraction data are only obtainable
through the use of synchrotron radiation sources. Thus regular synchrotron access is highly desirable to maintain a competitive advantage in our individual
research fields.

奥地利晶体学衍射联盟（Austrian Crystallographic Diffraction Consortium，ACDC）光束访问组（BAG）旨在为奥地利境内的多家大分子结构生物学研究团队提供支持，该团队涵盖4座城市9所机构的共计20个研究小组。本课题组主要采用X射线晶体学（X-ray crystallography）技术表征大分子生物复合物，同时也会频繁借助溶液散射技术（solution scattering approaches）解析动态组装体的结构特征。获批加入该BAG，是所有研究团队的科研人员开展相关结构生物学研究的必要前提，相关研究覆盖多项健康相关及基础科研主题，目标为解析当前在蛋白质数据库（Protein Data Bank，PDB）中占比偏低的大型分子组装体与蛋白质，其中包括膜蛋白（membrane proteins）。所需的高分辨率衍射数据仅可通过同步辐射光源（synchrotron radiation sources）获取，因此获取常规同步辐射束线使用权限，对我们在各自研究领域保持竞争优势而言至关重要。