Signature miRNA expression comparison between activated B cells and CLL cells relative to control B cells.

Up and down arrows indicate upregulation or downregulation of specific miRNAs, respectively, when compared to untransformed, control B cells. A parallel line indicates no change when compared to untransformed, control B cells. miR-223, miR-29a, miR-29b and miR-29c are upregulated in response to certain B cell activators and downregulated in response to other B cell activators. miR-26a is unaffected by IgM stimulation, but upregulated in response to other B cell activators.向上箭头与向下箭头分别代表，相较于未转化对照B细胞，特定微小核糖核酸（microRNAs，miRNAs）的表达上调与下调；平行线则代表相较于未转化对照B细胞，相关微小核糖核酸的表达水平无显著变化。miR-223、miR-29a、miR-29b及miR-29c可在部分B细胞激活剂的刺激下出现表达上调，而在另一些B细胞激活剂的作用下发生表达下调。miR-26a不受免疫球蛋白M（Immunoglobulin M，IgM）刺激的影响，但可在其他B细胞激活剂的作用下出现表达上调。