Investigating the conformational changes of OEA on HIF-3A-ARNT by HDX-MS
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https://www.omicsdi.org/dataset/pride/PXD033376
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We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to investigate the influence of OEA on HIF-3A-ARNT.HDX-MS data indicated that OEA binding stabilized multiple residues within the Gβ and Fα regions of HIF-3A PAS-B domain.It is possible that the stabilized Gβ and Fα function as an “interlayer” to further contact with the AB-loop of ARNT.
创建时间:
2022-05-20



