Institut Pasteur BAG - Structural biology of infectious agents

The Institut Pasteur’s BAG gathers the projects of the research units and platforms of the Institut Pasteur in Paris which are active in the field of structural biology: Structural Microbiology (P.M. Alzari), Structural Dynamics of Macromolecules (M. Delarue), Structural Virology (F. Rey) and the Platform of Crystallography (A. Haouz). A non-exhaustive list of ongoing projects includes: - actinobacterial cell division proteins, central metabolic enzymes and their complexes; - DNA gyrases, topoisomerases and regulators from mycobacteria or model organisms; - eukaryotic and archeal DNA polymerases and replisome proteins; - viral envelope proteins from pathogenic viruses, and their complexes with neutralizing antibodies; - enzymes and structural proteins from other human pathogens, supported by evolving national and international collaborations.巴斯德研究所（Institut Pasteur）的BAG数据集收录了巴黎巴斯德研究所各活跃于结构生物学领域的研究单元与平台的研究项目，涉及团队包括结构微生物学研究组（P.M. Alzari）、大分子结构动力学研究组（M. Delarue）、结构病毒学研究组（F. Rey）以及晶体学平台（A. Haouz）。目前在研项目的非完整列表涵盖以下内容： - 放线菌细胞分裂蛋白、核心代谢酶及其复合物； - 分枝杆菌或模式生物的DNA旋转酶、拓扑异构酶及其调控因子； - 真核与古核DNA聚合酶及复制体蛋白； - 致病病毒的包膜蛋白及其与中和抗体的复合物； - 其他人类病原体来源的酶与结构蛋白，相关研究依托不断拓展的国内外合作推进。