Loss of MRAP2 in MC4R Neurons Protect from Obesity-Associated Autonomic and Cardiovascular Dysfunctions

Aims: The melanocortin receptor accessory protein 2 (MRAP2), which is abundantly expressed in the brain including the hypothalamus, has emerged as a key regulator of melanocortin-4 receptor (MC4R) activity. We sought to delineate the physiological significance of MRAP2 in MC4R neurons, with a particular focus on metabolic, autonomic and cardiovascular functions.

研究目的：黑皮质素受体辅助蛋白2（MRAP2）在包括下丘脑在内的大脑中广泛高表达，现已成为黑皮质素4受体（MC4R）活性的关键调控因子。本研究旨在阐明MRAP2在MC4R神经元中的生理学意义，重点关注其代谢、自主神经及心血管功能。