INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer's disease

Spatial Transcriptomics (Visium) of 12 coronal brain sections from 6 months old female Inpp5dfl/fl/Cx3cr1CreER/+ crossed to APPKM670/671NL/PSEN1?exon9 (PSAPP) mice and treated with either cornoil or tamoxifen (75 mg/kg) at 3 months of age for 5 consecutive days Overall design: Spatial Transcriptomics of Inpp5dfl/fl/Cx3cr1CreER/+ crossed to APPKM670/671NL/PSEN1?exon9 (PSAPP) mice to study the transcriptomics, brain-region resolved effect of removing Inpp5d from microglia in an animal model of Alzheimer's disease