Risk of AIDS and/or death according to combinations of clinical and immunological definitions of severe PHI.

a- bronchitis, pneumonia, oral candidiasis, thrombocytopenia, viral meningitis, bacterial meningitis, encephalitis, neuropathy, Candida pharyngitis.b- viral meningitis, bacterial meningitis, encephalitis, neuropathy.*Adjusted for sex, risk group (sex between men, injecting drug use, sex between men and women, other/unknown), age at HIV seroconversion (≤30 and >30 years) and first CD4 count (500 cells/mm3).¤Adjusted for sex, risk group (sex between men, injecting drug use, sex between men and women, other/unknown), age at HIV seroconversion (≤30 and >30 years).¥Long rank test for difference in survivor probabilities.§Cox semiparametric survival model.†Heterogeneity test for categorical variables.‡The symbol “-” for median survival time indicates that fewer than 50% of patients at risk have experienced the event by the end of follow-up.