Supplementary Material for: Cushing’s Syndrome in Adenocarcinoma of Lung Responding to Osilodrostat

Cushing syndrome (CS), secondary to paraneoplastic syndrome, is more commonly seen in small cell lung cancer (SCLC) but never before reported in EGFR-mutated adenocarcinoma of the lung. Here, we present a case of a patient whose symptoms of hypokalemia, hypertension and progressive abnormal glucose levels led to further workup that revealed ACTH-dependent hypercortisolism. Her cortisol levels dropped after one month of osilodrostat treatment while lung cancer was treated with osimertinib. The use of osilodrostat in paraneoplastic CS has been previously reported in only 3 patients.

继发于副肿瘤综合征（paraneoplastic syndrome）的库欣综合征（Cushing syndrome），在小细胞肺癌（small cell lung cancer, SCLC）中更为多见，但此前从未有报道见于表皮生长因子受体突变型肺腺癌（EGFR-mutated adenocarcinoma of the lung）患者。本文报告1例患者，其以低钾血症（hypokalemia）、高血压（hypertension）及进行性血糖异常为临床表现，经进一步检查确诊为促肾上腺皮质激素依赖性皮质醇增多症（ACTH-dependent hypercortisolism）。患者接受奥西卓司他（osilodrostat）治疗1个月后皮质醇水平出现下降，同期肺癌采用奥希替尼（osimertinib）进行治疗。此前仅报道过3例副肿瘤性库欣综合征患者使用奥西卓司他治疗的案例。