The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats

Abstract Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.

摘要 目的：评估全身应用环磷酰胺（cyclophosphamide）对大鼠子宫的影响，并探究天然抗氧化制剂姜黄素（curcumin）与辣椒素（capsaicin）对抗环磷酰胺不良反应的潜在治疗作用。方法：本研究选用40只健康成年雌性Wistar白化大鼠，按随机原则分为四组（每组n=10），以探究姜黄素与辣椒素对环磷酰胺所致子宫损伤的对抗作用；第1组为假手术对照组，第2组为环磷酰胺单独给药组，第3组为环磷酰胺联合姜黄素（100mg/kg）给药组，第4组为环磷酰胺联合辣椒素（0.5mg/kg）给药组。结果：仅接受全身环磷酰胺化疗的大鼠子宫组织氧化应激水平升高，并出现组织学损伤；姜黄素与辣椒素给药可改善子宫组织的氧化/抗氧化标志物水平及组织病理学改变。结论：姜黄素与辣椒素可对抗环磷酰胺等烷化剂类化疗药物对子宫产生的细胞毒性损伤。